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In the latter conformation, the rAmy bypass motif becomes disordered, enabling the receptor ECD to adopt a position similar to CT-bound CTR or AMYR complexes 15

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GSH is the essential co-substrate for the glutathione peroxidase (GPx) family including GPx4, which converts toxic lipid peroxides into non-toxic alcohols and is central to ferroptosis research and for glutathione S-transferases (GST)

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Lack of sleep and stress can decrease glutathione levels